خلاصة:
Purpose: The aim of this study was to investigate the effects of six weeks of aerobic training, with and without extract of Jujuba, on fundus nesfatin-1, ATP concentration, plasma High-density lipoprotein (HDL), and Low-density lipoprotein (LDL) levels in female rats.Material and Methods: 28 Wistar rats were randomly assigned to Saline-control, Saline-training, Jujuba-control and Jujuba-training groups. Training groups were given exercise on a motor-driven treadmill at 35 m/min (0% grade) for 60 min/day and 5 days/week for six weeks. Animals were fed orally, with Jujuba extraction and Saline (3 weeks, 60 mg per 100 g body weight). 72 hours after the last training session and after four hours of fasting, the rats were sacrificed, and their fundus tissue was excised. Some plasma was also collected for plasma variable measurements. All variables were compared using one way analyzes of variances. Correlations were calculated using the Pearson Product Moment correlation. All P values <0.05 were considered as significant.Results: nesfatin-1 significantly increased in saline training group compared to saline control group (P<0.028). Exercise training (P<0.091) and extraction (P<0.031) independently increased plasma HDL-C and decreased fundus ATP (P<0.002). There was no significant difference between groups regarding plasma LDL concentration. There was also no correlation between fundus nesfatin-1 concentration and plasma HDL, LDL and fundus ATP.Discussion and Conclusion: Exercise and using Jujuba extraction may prevent over-weight and cardiovascular diseases.
ملخص الجهاز:
"Key Words: Aerobic training, Nesfatin-1, Female rat, Zizyphus jujuba water extraction Introduction Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals and central signals, in particular, neuropeptides [1, 2].
Solati et al (2010) investigated the effects of water extracts of Ziziphus fruit on serum glucose, triglycerides, LDL- cholesterol, and HDL-cholesterol in diabetic adult male rats.
Thus, the current study was to investigate the effects of six weeks of aerobic training with and without Jujube extraction, on fundus nesfatin-1 concentrations in female rats.
Discussion and Conclusion The aim of this study was to investigate the effects of six weeks of aerobic training with and without extract of Jujuba, on fundus nesfatin-1 and ATP concentrations, plasma HDL and LDL concentrations in female rats.
Previous study showed that nesfatin-1was (رجوع شود به تصویر صفحه) expressed in different tissues including the rats Exercise Figure 1: Fundus nesfatin-1 concentration in Saline-control, Saline-trained, Jujuba-control and Jujuba- trained groups of wild-type female rats.
However, Ghanbari-Niaki et al (2010) focused on the effects of two different anaerobic exercise sessions (anaerobic sprint test RAST: 7 sets of 6 × 35 m every 10 s with 1 min rest between sets and a non-combat kickboxing session: 7 sets of 6 techniques, 20 s per technique with 1 min rest between sets) on plasma nesfatin-1 concentrations in human subjects [26].
Ghanbari- Niaki et al (2012, unduplicated data), investigated the effects of eight weeks of aerobic training on tissue nesfatin-1/nucleobindin-2 expression and its plasma concentration."