ملخص الجهاز:
"Animal Model of PTSD: Behavioral Changes Following Underwater Trauma, Situational Reminders and Diazepam Treatment Shahrokh Makvand-Hosseini, Ph. D.
Different stressors have been applied to induce long-term behavioral effects in animals and were proposed to model PTSD, including electric shocks(Li, 2006; Shimizu, 2006; Wakizono et al, 2007), predator exposure(El Hage, 2004, cooper, 2005;Adamec, 2008) and underwater stress(Armario, 2008, Richter-Levin G.
This research is a replicate of rats' behavioral changes in the elevated plus maze test following exposure to intense stressful experience of breathing deprivation induced by underwater trauma, short term exposure to situational reminders (SRs) after traumatic event and subsequent low dose diazepam treatment in the female rats.
Experimental design and procedure: After the ethical-committee approval and animal guidelines in the Semnan University experiment was designed in three stages using the following procedures: Stage 1- Baseline: rats' behavior in the elevated plus maze test were recorded for 5 successive days before exposure to any traumatic event.
05df: 5 Discussion The present research was evaluated the effects of traumatization (underwater trauma and SR exposure) on the behavioral parameters in the EPM test (open arm ratio time and ratio entry) and the potential pharmatherapeutic effects of diazepam (0/5 mg/kg) in Sprague-Dawley rats to create an animal model of PTSD.
Overall, the underwater trauma and exposure to situational reminders of the traumatic event successfully was induced PTSD sequels in rats and short term diazepam injection was decreased the pathological symptoms."