خلاصة:
Purpose: It was shown that with acute low-intensity exercise that is minimally stressful, hippocampus activation and BDNF expression can be achieved lending support to the idea that mild exercise could yield greater benefits in hippocampus functions compared to the more strenuous forms. The neuroprotective effects of acute workout training on lead acetate-induced BDNF levels were investigated. Materials and Methods: Thirty -two adult, male, Wistar rats were randomly classified into 4 groups; Rats were randomly assigned to 1) basic group (Base-B, n = 10), 2) control group (lead-L, n=10) 3), lead injection group (acute pre, n=10) and 4) treadmill exercise with lead injection group (acute post, n=10). The rats in groups 3 and 4 experienced the treadmill running 15 to 22m/min, 25 to 64minutes, 5 times a week, and for 8 weeks. Groups 3 and 4 received lead acetate (20 mg/kg) and the sham group received solvent (ethyl oleat). Results: The results showed that BDNF in Lead acetate group decreased significantly whereas it increased in
Lead acetate + Workout group. Obtained data suggest a lifestyle-induced protective potential in rehabilitation of lead-induced neurodegeneration. Discussion and Conclusion: findings from the present research indicated the significant role of exercises in improving BDNF level. Increased level of BDNF may act as neuroprotector in recovery from numerous disturbances, such as reduction of the brain weight, memory loss and different degenerative processes. It may be concluded that the increase of BDNF in hippocampus may cause positive plastic changes and prevent the
mentioned disturbance.
ملخص الجهاز:
"Orbeli Institute of Physiology, NAS of Armenia, Yerevan, Armenia Received 6 June 20137 November 2011 Accepted 4 August 2013 Abstract Purpose: It was shown that with acute low-intensity exercise that is minimally stressful, hippocampus activation and BDNF expression can be achieved lending support to the idea that mild exercise could yield greater benefits in hippocampus functions compared to the more strenuous forms.
Acute workout, Brain-derived neurotrophic factor, Hippocampus, Lead acetate Introduction It has been suggested that physical exercise modulates cognitive functions through various signaling mechanisms that lead to brain-derived neurotrophic factor (BDNF) up-regulation, especially in the hippocampus, a major hub for learning and memory formation [1,2].
It was also shown that acute workout leads to improvements in performing a hippocampal-based cognitive task, which may be related to a concomitant increase in circulating BDNF concentrations.
Although chronic voluntary physical activity has been shown to enhance hippocampus BDNF expression in animals, the effects of forced exercise on a treadmill have not been reasonably investigated.
To resolve this, in this study, we used a special treadmill running protocol in order to examine hippocampus activation and BDNF expression and present evidence that acute workouts differentially affect the time-course of BDNF induction in various regions of the rat hippocampus.
Physical exercise modulates hippocampal neurogenesis [26], reduces oxidative stress [27], increases brain-derived neurotrophic factor levels [28], and brain vascularization [29], and causes a variety of morphological changes."