خلاصة:
Purpose: The present paper studied the effects of 8 weeks of aerobic training and Ferula gummosa on apelin and stress markers in heart and kidney tissues of hypertensive rats. Fifty adult, male, Wistar rats were randomly classified into five groups: aerobic training (AT), Ferula gummosa (FG), combination of aerobic training and Ferula gummosa (TFG),nitro-L-arginine-methyl ester(L-NAME) and sham (SH). Material and Methods: Training program included treadmill running, 25-64 min per session, 15-22 m/min, 5 sessions a week, for 8 weeks. The FG supplement group (90 mg/kg) was fed through gavage. Hypertension was induced by L-NAME solution, intraperitoneally (10 mg/kg),
for 8 weeks, 6 sessions a weekone-way ANOVA and Welch test for repeated measurements with post hoc testing by Tukey were performed to identify differences between groups.
Results: AT, FG, and TFG protocols resulted in an increase in apelin, Nitric oxide (NO) in heart
and kidney tissues and significantly decreased angiotensin converting enzyme (ACE) as compared to L-NAME group. TFG protocols resulted in an increase in apelin and NO in the heart tissue as
compared to sham group. In addition FG resulted in an increase in NO and apelin levels in heart
and kidney tissues as compared to L-NAME group. Discussion and Conclusion: It seems that aerobic exercise with moderate intensity and herbal supplements of apiaceae increase apelin and reduce blood pressure in rats with hypertension. This study provides the experimental evidence showing that the apelin has hypotensive and cardio protective effects in the kidney and heart tissues of rats.
ملخص الجهاز:
"Received 17 December 2012 Accepted 5 July 2013 Abstract Purpose: The present paper studied the effects of 8 weeks of aerobic training and Ferula gummosa on apelin and stress markers in heart and kidney tissues of hypertensive rats.
Despite the knowledge that hypertension can induce oxidative stress [12,14] on one hand, and taking into account , the effects of these peptides on blood pressure in different tissues on the other, little evidence is available with respect to individual and concomitant effects of regular aerobic training and turmeric antioxidant supplement on cardiac apelin and the oxidant/antioxidant and inflammatory processes particularly during chronic exposure to L-NAME- induced hypertension.
The purpose of the current study was to determine the effects of aerobic exercise, and Ferula gummosa supplementation on cardiac and renal apelin in rats that have been chronically exposed to L-NAME-induced hypertension.
In addition, APJ-deficient mice showed an increased vasopressor response to the combination of aerobic exercise and Ferula angiotensin II, and the baseline blood pressure of gummosa significantly increased cardiac apelin and double mutant mice homozygous for both APJ and NO as compared to the L-NAME groups.
In conclusion, it seems that aerobic exercise with moderate intensity and apiaceae herbal supplementation increased apelin and reduced blood pressure in rats with hypertension, which along with other treatment methods, may suggest a new approach to heart and renal protection against hypertension-induced chronic stress .
Furthermore, Ferula gummosa supplementation and/or aerobic training had useful effects on reducing the L-NAME-induced hypertension, probably through increasing apelin effects and decreasing the oxidative, inflammatory and endothelial dysfunction biomarkers related to hypertension."