خلاصة:
Introduction: Cardiac Troponin T (cTnT) is currently
considered as an ideal biomarker for the diagnosis of cardiac
injury and Metallothionein has a protective effect against
oxidative species damage. The aim of the present study is to
investigate the effect of 8 weeks of aerobic activity on
Troponin T levels and Metallothionein of cardiac tissue in
healthy male rats.
Material & Methods: In this study, 20 Wistar male rats, aged
2 months with the weighted average of 180 ± 20 g, were
selected and randomly divided into 2 groups: aerobic exercise
(10) and control (10). The exercise group performed physical
exercise 5 days a week according to the training program for
8 weeks. During this period, the control group did not
exercise at all. After 8 weeks of training, independent t- test
was used to analyze the data.
Results: The results demonstrated there was no significant
difference between the average Troponin T (P=0.77) in the
exercise and control groups. No significant difference was also
observed between Metallothionein in the training and control
groups (P=0.15).
Conclusions: It was revealed that the aerobic program used
in the present study did not lead to increased cTnT which is
indicative of cardiac injury. However, it increased
Metallothionein levels (though insignificant) that can be
helpful in preventing cardiac injury.
ملخص الجهاز:
The effect of eight weeks aerobic exercise on troponin T and metallothionein levels of cardiac tissue in healthy male rats Saeedeh Shadmehri1, Maryam Shabani2, Farhad Daryanoosh3*, Mohammad Sherafati Moghadam2 Received: 4 November 2017/ Accepted: 15 January 2018 (1) Associate professor in exercise physiology, Department of Physical Education and Sport Sciences, Islamic Azad University, Yadegar-e-imam Khomeini (RAH) Shahr-e Ray Branch, Tehran, Iran.
ir Abstract Introduction: Cardiac Troponin T (cTnT) is currently considered as an ideal biomarker for the diagnosis of cardiac injury and Metallothionein has a protective effect against oxidative species damage.
The aim of the present study is to investigate the effect of 8 weeks of aerobic activity on Troponin T levels and Metallothionein of cardiac tissue inhealthy male rats.
47 Material & Methods: In this study, 20 Wistar male rats, aged2 months with the weighted average of 180 ± 20 g, were selected and randomly divided into 2 groups: aerobic exercise (10) and control (10).
In another study, Chen and colleagues (2008) investigated the protective effects of exhaustive exercise on Metallothioneins in the heart of rats with infarction.
Accordingly, the overall goal of this study is to examine the effect of 8 weeks of aerobic activity on Troponin T levels and Metallothionein of cardiac tissue in healthy male rats.
In order to determine significant differences in the levels of troponin T and Metallothionein in the exercise and control groups, independent t- test was utilized.
(2012) examined the effect of a progressive aerobic exercise program on MT levels of cardiac tissue in Wistar rats.