خلاصة:
<em>Introduction:</em> Many studies documented the relationship between elevated plasma concentrations of brain natriuretic peptide (BNP) and its aminoterminal propeptide (NT-proBNP) and cardiovascular diseases, especially heart failure (HF). However, it is still uncertain whether physical exercise leads to a significant release of NT-proBNP in healthy subjects. The aim of this study was to determine the effect of an exhaustive aerobic exercise on NT-proBNP levels in healthy males.<br /> <em>Material & Methods:</em> In this study, Fifteen healthy male (aged: 22.2 ± 2.3 years; ± SD) volunteered to participate in this study. The subjects were performed Bruce protocol as the exhaustive aerobic exercise. NT-proBNP plasma concentrations were measured before and immediately after the exhaustive aerobic exercise. Paired-sample t- test was used to analyze the data.<br /> <em>Results:</em> The results demonstrated that NT-proBNP levels were increased significantly after the exhaustive aerobic exercise (P<0.05). We did not find any correlation between the post-exercise increase of NT-proBNP levels and body mass index (BMI), body fat percentage (%BF) or VO<sub>2max</sub>.<br /> <em>Conclusions</em><em>:</em> In conclusion, the exhaustive aerobic exercise in healthy individuals led to a fast rise of plasma NT-proBNP concentrations.
ملخص الجهاز:
The effect of an exhaustive aerobic exercise on NT-proBNP levels in healthy males Mohammad Ghassami1* and Saeid Naraghi1 Received: 20 January 2018/ Accepted: 13 April 2018 (1) MS in exercise physiology, Department of Exercise physiology, Marvdasht branch, Islamic Azad University, Marvdasht, Iran (*) MS in Exercise physiology; E.
com Abstract Introduction: Many studies documented the relationship between elevated plasma concentrations of brain natriuretic peptide (BNP) and its aminoterminal propeptide (NT- proBNP) and cardiovascular diseases, especially heart failure (HF).
The aim of this study was to determine the effect of an exhaustive aerobic exercise on NT-proBNP levels in healthy males.
Increased plasma concentrations of natriuretic peptides were also found in patients with acute coronary syndromes, even in those without myocardial necrosis or accompanying heart failure (4).
Previous studies indicated that regular and continuous aerobic exercise, strength exercise and combined endurance/resistance exercise reduces NT-proBNP levels in healthy and heart failure (HF) patients (5-7).
Several studies have documented that transient ischemia induced by exercise stress testing triggers the release of BNP and NT-proBNP (8,9).
Several studies documented the relationship between natriuretic peptides rise and the severity of ischemia during exercise stress testing in patients with coronary artery disease or healthy subjects (2,7-9,12,13).
Another study described the exercise induced elevation of plasma BNP levels in patients with chronic heart failure (14).
(2004) reported that plasma levels of BNP and NT-proBNP in subjects without ischemia during exercise did not change significantly within 4 hours after stress testing (9).