خلاصة:
<em>Introduction:</em> Elevated levels of galectin-3 have been found to be significantly associated with higher risk of death in both acute decompensate heart failure and chronic heart failure populations. Although endurance exercise is a crucial element in cardiovascular disease prevention, the relationship between exercise and plasma levels of galectin-3 is still unknown. The aim of this study was to determine the effect of an exhaustive aerobic exercise on galectin-3 levels in healthy males.<br /> <em>Material & Methods: </em>Fifteen healthy male (aged: 22.2 ± 2.3 years; ± SD) volunteered to participate in this study. The subjects were performed Bruce protocol as the exhaustive aerobic exercise. The blood sample was taken before and immediately after the completion of the exhaustive aerobic exercise. Wilcoxon test and Spearman correlation test were used to analyze the data.<br /> <em>Results:</em> The results demonstrated that galectin-3 had no significant changes in response to the exhaustive aerobic exercise (297.6 ± 180.5 vs. 294.9 ± 190.3 pg/ml). No significant correlation was observed between the post-exercise levels of galectin-3 with body mass (r = 0.1, P = 0.7), BMI (r = ‒ 0.1, P = 0.7), body fat percentage (r = 0.06, P = 0.8), WHR (r = 0.02, P = 0.9), or VO<sub>2max </sub>(r = 0.2, P = 0.4).<br /> <em>Conclusions</em><em>:</em> In conclusion, the exhaustive aerobic exercise had not significant effects on galectin-3 concentrations in healthy individuals.
ملخص الجهاز:
The aim of this study was to determine the effect of an exhaustive aerobic exercise on galectin-3 levels in healthy males.
Keywords: Galectin-3, Biomarker, Exhaustive aerobic exercise, Heart failure 1.
Change on NT-proBNP levels before and after the exhaustive exercise There were no significant relationships between the Galectin-3 levels with body mass, BMI, body fat percentage, WHR or VO2max (Table 2).
Clinical studies have shown that high circulating Galectin-3 levels are indicative of severity of heart diseases or associated with increased risk of major adverse cardiovascular events including heart failure (7), arrhythmias (23), arterial stiffening (24), re-hospitalization post heart failure discharge (25), diastolic dysfunction (26), severity of atrial fibrosis (27) or mortality (28).
Thus the purpose of this study was to investigate the effect of an exhaustive aerobic exercise on galectin-3 levels in healthy males.
Thus the purpose of this study was to investigate the effect of an exhaustive aerobic exercise on galectin-3 levels in healthy males.
Clinical studies demonstrated that while increased cardiac Galectin-3 expression was observed in human cardiac biopsies (27,32), cardiac release of Galectin-3 is not evident in patients with atrial fibrillation or severe heart failure indicated by the absence of a trans-cardiac Galectin-3 gradient (33).
(2018) indicated that activation of β-adrenoceptors leads to increased cardiac and circulating levels of Galectin-3 in healthy or cardiomyopathy hearts (41).
The effect of an exhausting aerobic exercise session on plasma NT-proBNP and galectine-3 levels in male runners.
Mechanisms responsible for increased circulating levels of galectin-3 in cardiomyopathy and heart failure.