Assessment atherosclerosis and Visfatin, Leptin Levels in Type 2 Diabetic Patients in Babylon Province مقالة

Aims: Chronic hyperglycemia produced by insulin synthesis, action, or both characterizes diabetes mellitus. Leptin, Visfatin, sex steroids, and several growth factors are adipose tissue hormones that work in the endocrine system. These hormones also affect immunity. This study examined serum Leptin, Visfatin, and atherosclerosis status in T2DM patients with dyslipidemia. ELISA was used to identify 90 participants: 30 healthy controls (Group 1), 30 DM with atherosclerosis (Group 2), and 30 DM (Group 3). Visfatin and leptin were g. (Group 1). Our data imply that Leptin Visfatin excess may contribute considerably to DM. type 2. More study with larger patient groups is needed to determine these markers' functions. Assessment of Atherosclerosis and Visfatin, Diabetes Mellitus Type 2 and Leptin Serum Levels in Patients from the Province of Babylon. Material and methods: 30 patients with DM Type 2, 30 seemingly healthy controls, and 30 DM patients with atherosclerosis who were comparable in age and BMI were studied. College of Medicine, University of Babylon, Chemistry Department, did this investigation. Study doctors classified 60 patients with DM Type 2 symptoms for more than three months. 30 control group participants were normal clinic patients without DM symptoms. They were registered at Babylon Center for Diabetes and Endocrinology in Hilla city Babylon province and Iraqi Center for Cardiac Surgery in Baghdad Governorate., between (October 2022 and November 2022). There were a total of 90 patients, Leptin, Visfatin were measured for patients by ELISA method, in addition to SPSS software was used to conduct the statistical analysis. Results: This research included 90 type 2 diabetics (group 1) The control group (group2) was thirty with mean gender and body mass index, while the diabetic mellitus type 2 patients (group3) had substantial increases in Visfatin levels and greater atherosclerosis than controls. DM patients also had higher Visfatin levels than DM + atherosclerosis patients. Conclusion: Visfatin serum levels were found to be significantly higher in atherosclerosis patients compared to healthy control subjects in both the male and female subgroups of this study (P 0.01), while low leptin and high Visfatin expression was seen in patients with DM. Progression of insulin resistance has been found to be connected with dysregulation of the adipoinsular axis, in which leptin inhibits insulin synthesis via a negative feedback loop while insulin increases leptin production. hormone leptin can be used as a predictor of both obesity and type 2 diabetes; serum leptin levels in type 2 diabetic patients and their correlations with other clinical factors (such as body mass index, insulin concentration, and waist circumference) are not well understood.