Cerebral Palsy and Patterns of Magnetic Resonance Imaging (MRI): a Review مقاله

Cerebral Palsy is the most common chronic motor disorder of childhood, that affecting approximately 3 infants per 1000 live-births. The risk of brain injuries that potentially cause Cerebral Palsy has amplified with increasing in survival rates for preterm infants. In addition Cerebral Palsy has a huge economic impact, to immeasurable health, social, and psychological problems that affected children and their families suffer. Cerebral Palsy, among 18 common congenital disorders, has the highest lifetime costs per new case. Thus, efforts to prevent its occurrence, minimize the morbidity, and improve the patient outcomes are important at both the individual and societal levels. In each trimester, different patterns of brain damage or abnormal insults can represent times and etiology of injuries. Knowledge of the etiology and pathogenesis of abnormal brain growth during antenatal, perinatal and neonatal damages can be helping us for prevention. Also Magnetic Resonance Imaging (MRI) studies of subjects with multiple forms of cerebral palsy reported significantly more overall abnormalities, malformations, and white matter damage but in this review study we discuss in what extent MRI is useful in detecting cerebral palsy pathogenesis.

Iranian Rehabilitation Journal, Vol. 12, No. 22, December 2014 Review Cerebral Palsy and Patterns of Magnetic Resonance Imaging (MRI): a Review Farin Soleimani, MD. Pediatric Neurorehabiliation Research Center University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Fereshteh Narenji*; Masomeh Poormohsen1; Khosheh Khaleghinejad1; Nahid Mehran1 Shahid Behshti University of Medical Science, Tehran, Iran Cerebral Palsy is the most common chronic motor disorder of childhood, that affecting approximately 3 infants per 1000 live-births. Also Magnetic Resonance Imaging (MRI) studies of subjects with multiple forms of cerebral palsy reported significantly more overall abnormalities, malformations, and white matter damage but in this review study we discuss in what extent MRI is useful in detecting cerebral palsy pathogenesis. Also magnetic resonance imaging (MRI) studies of subjects with multiple forms of cerebral palsy reported significantly more overall abnormalities, malformations, and white matter damage but the question is, what extent MRI is useful in detecting cerebral palsy pathogenesis? MRI of the brain demonstrated hypoxic- ischemic findings in all neonates born with perinatal asphyxia who later progressed to cerebral palsy. The hallmark of acute perinatal hypoxia-ischemia in term infants, central grey matter damage, is an important cause of death and cerebral palsy. However, the reports indicated that originally the most cases of CP result around the time of birth (40%), and the most white matter lesions had occurred in perinatal period (44%) and their greatest risk is between 23 and 32 weeks of pregnancy, although these lesions are common in term infants with CP (12).