چکیده:
Background. Previous surveys have shown that motor deficits precede the classical motor symptoms seen in
Parkinson’s disease (PD) and that physical exercise may have beneficial effects on PD. Objectives. Here, we
evaluated the potential of voluntary exercise to improve motor deficit in experimentally-induced Parkinson’s
disease (6-OHDA) rats. Methods. Forty adult Wistar rats were randomly assigned to four groups: (1)
untrained-vehicle (2) untrained-Parkinson’s (3) running wheel (RW)-vehicle and (4) RW-Parkinson’s. Exercise
groups were given free nocturnal access for over four weeks. The motor function, balance and strength were
respectively measured by Rotarod and hanging test. Results. The data showed that voluntary exercise groups
had a significant increase in balance (p<0.05) and strength (p<0.05), when compared to control groups.
Running wheel improved motor function in animals induced by 6-OHDA. Conclusion. Thus, our results
reinforce the potential of voluntary exercise as a useful tool for reducing motor symptoms associated with
Parkinson’s disease.
خلاصه ماشینی:
"Effects of Voluntary Exercise on Motor Function in Parkinson's disease Model of Rats 1Forouzan Rafie, 2Mehdi Shahbazi*, 2Mahmoud Sheikh, 3Nasser Naghdi, 1Vahid Sheibani, 1Neuroscience Research Centre, Kerman University of Medical Sciences, Kerman, Iran.
Here, we evaluated the potential of voluntary exercise to improve motor deficit in experimentally -induced Parkinson’s disease (6-OHDA) rats.
Parkinson, Voluntary Exercise, Balance, Strength, Motor Function INTRODUCTION Parkinson’s disease (PD) is a common neurodegenerative disorder that affects people over 50 years (1, 2).
Therefore, in this study, we want to consider the effects of four weeks of voluntary wheel running on motor function in 6-OHDA rat models with Parkinson’s disease.
Decreased latency to fall from the wire could attenuate hypokinesia and motor weakness (strength and power) in rats with Parkinsonism to some extent; this confirms preliminary findings in previous studies (22) that wheel running exercise significantly improved strength and power in PD rats.
In summary, 6-OHDA lesions do impair motor function and our results strongly suggest that voluntary exercise plays a significant role in motor coordination, reducing strength deficits in an animal model of Parkinson’s disease; this result is in accordance with previously published data (28, 29).
As previous studies reported, 6-OHDA lesion caused motor abnormality, and from the results of this study, it is apparent that PD groups presented significant neuromuscular and power impairments compared with the sham and control groups, as indicated by a reduction in the time of falling.
Voluntary exercise can improve the motor function in a 6-OHDA- induced rat model of Parkinson’s disease."