ملخص الجهاز:
"As mentioned above, serum neuregulin, particularly NRG1 is changing at different circumstance, specially in schizophrenia, diabetes, and might be in physical exercise as a metabolic and cardiovascular stressor (20-22).
(2014) study, they reported that rats underwent 4weeks resistance training resulted in up-regulated NRG1 protein expression of cardiac and skeletal muscle in male trained rats ,Erb B2 and Erb B4 expressions were both up-regulated in male and female rats.
Author concluded that resistance training could promote cardiac function and skeletal muscle growth in female and male trained rats, increase NRG1 expression and its receptors in myocardial tissue and gastrocnemius muscle, and these changes are different between male and female rats (26).
On the basis of the present study results, authors hypothesized that endurance training might be more effective than resistance training to induce significant changes in NRG1 cleavage in skeletal muscle.
The effect of exercise training (16m/min, 50min, 5 days/week for 4 weeks) on NRG1/ErbB signal pathway in rat myocardial infarction model was investigated by Cai et al.
CONCLUSION On the basis of reviewed studies, it seems that NRGs and its receptors are not expressed and functioned in nerous system particularly brain, but it also expressed in different tissues such as heart, skeletal muscle, adipose tissue, and means that NRGs isoforms paly different biological and developmental role in different tissues.
The expression of neuregulin and erbB receptors in human skeletal muscle: effects of progressive resistance training.
Effects of Resistance Training on NRG1 Express of Heart and Skeletal Muscle in Different Gender Rats with Myocardial Infarction."