Abstract:
Objectives: Genetic polymorphism interactions are among the important factors in affliction with complex diseases like Alzheimer’s disease. The important goal of genetic association studies is to identify a combination of polymorphisms and measure their importance in increasing the risk of occurrence of such diseases. In this study, feature selection approach of logic regression was used to identify the interactions among genetic polymorphisms influential in patients affected with Alzheimer’s disease. Method and Materials: 101 Alzheimer’s cases and 109 control subjects from Iranian population were recruited in a case-control study. The evaluation of genes in two groups was performed using molecular technique methods in particular, the PCR-RFLP technique was used to evaluate the intended polymorphisms in APOE, ABCA1, CALHM, CCR2, GSK3β, SAITOHIN, TAU, TNF-α and VDR genes, and then the feature selection approach was used to detect the significance polymorphisms and interactions between them. Results: Based on feature selection approach, the two-way interaction between the polymorphisms of SAITOHIN and APOE genes were significant on occurrence of Alzheimer’s disease. Conclusion: Logic regression approach is recommended to detect interaction in the genetic association studies.
Machine summary:
The important goal of genetic association studies is to identify a combination of polymorphisms and measure their importance in increasing the risk of occurrence of such diseases.
In this study, feature selection approach of logic regression was used to identify the interactions among genetic polymorphisms influential in patients affected with Alzheimer’s disease.
The evaluation of genes in two groups was performed using molecular technique methods; in particular, the PCR-RFLP technique was used to evaluate the intended polymorphisms in APOE, ABCA1, CALHM, CCR2, GSK3β, SAITOHIN, TAU, TNF-α and VDR genes, and then the feature selection approach was used to detect the significance polymorphisms and interactions between them.
Results: Based on feature selection approach, the two-way interaction between the polymorphisms ofSAITOHIN and APOE genes were significant on occurrence of Alzheimer’s disease.
Keywords: Logic regression, Feature selection, Interactions, Genetic Polymorphisms, Alzheimer’s disease Submitted: 12 Dec 2010 Accepted: 04 Mar 2011 Introduction Single nucleotide polymorphism (SNP) is a minor genetic variation which can occur in DNA sequence.
In order to detect the interactions of genetic polymorphisms of the noted genes and genotypes of APOE gene in affliction with Alzheimer, the Feature selection approach of logic regression was used.
In this article, feature selection which is a combination of bootstrap and logic regression methods was used to determine potential individual and interaction effects between genetic polymorphisms influential in affliction with one-late Alzheimer and then the two indexes of VIMsingle and VIMmultiple were used to quantify the importance of the specified effects and based on it, one interaction effect of the polymorphisms of APOE and SAITOHON genes was determined.