Abstract:
Background. Moyenctin, is a new identified myokine and belongs to the CTRPs family which plays role in lipid and
glucose metabolism. There is limited information available regarding the effects of exercise training on serum
myonectin levels. Objectives. he aim of this study was to investigate the effects of sucrose solution intake and
resistance training (RT) with two different volumes on serum myonectin levels and HOMA-IR in rats. Methods.
Forty-eight male Wistar rats (10-12 weeks old) were randomly divided into six groups; Control (C), Low volume RT
(L), High Volume RT (H), Sucrose Control (SC), Sucrose Low volume RT (SL) and Sucrose High volume RT (SH).
The RT groups were subjected to a resistance training program with the use of a ladder (3 days/week, for 8 weeks).
Body weight and serum levels of myonectin, insulin, glucose, and HOMA-IR were measured. Results. The results
two way ANOVA showed that interaction between RT and sucrose solution significantly increased serum levels of
insulin (P=0.007) and HOMAL-IR (P=0.002). Consumption of sucrose solution, significantly reduced serum
myonectin (P=0.0001) and increased serum glucose, insulin and HOMA-IR (P=0.0001). Also RT significantly
reduced serum myonectin, insulin and HOMA-IR (P=0.0001). No correlation was found between serum myonectin
and insulin resistance in groups fed with normal foods (P=0.456), but in the groups fed with sucrose solution there
was positive and significant correlation (P=0.0001). Conclusion. This data indicated that resistance training
regardless of volume of training can reduce serum myonectin levels as well as insulin resistance in rats fed with
sucrose solution or normal diet groups.
Machine summary:
"Effect of Resistance Training with Two Different Volumes on Serum Myonectin Levels in Rats Fed with Sucrose Solution 1Majid Adigozalpour, 1Alireza Safarzade* 1Department of Exercise Physiology, Faculty of Sport Science, University of Mazandaran, Babolsar, Iran.
he aim of this study was to investigate the effects of sucrose solution intake and resistance training (RT) with two different volumes on serum myonectin levels and HOMA-IR in rats.
This data indicated that resistance training regardless of volume of training can reduce serum myonectin levels as well as insulin resistance in rats fed with sucrose solution or normal diet groups.
Therefore, taking into consideration the abovementioned factors, the aim of this study was to investigate the effect of sucrose solution consumption and resistance training with two different volumes on serum myonectin levels and insulin resistance index.
The results also showed that there is a significant posi tive correlation between the myonectin levels and insulin resistance index in the groups fed with sucrose solution p=0.
This study showed that eight weeks of resistance training—regardless of the volume of training—significantly reduces myonectin levels in all training groups fed with sucrose and normal, compared to the control group.
In the present study, myonectin serum levels decreased after eight weeks of resistance training in all rats, including normal and those fed with sucrose.
The results also showed that there is a significant positive correlation between the serum levels of myonectin and insulin resistance index in the groups fed with sucrose solution."