Abstract:
Background. the basal ganglia’s circuit dysfunction has a major role in a range of movement disorders. Some
evidence has shown that exercise can improve performance, especially locomotor activity after brain injuries. There
was currently insufficient information to define the impacts of intensity, duration, and frequency of different
exercises. Objectives. in this study, we examine the role of mild forced treadmill exercise and GABA-B agonist on
locomotor activity and anxiety-behavior dysfunction of ibotenic acid injection in striatum. Methods. forty male
Wistar rats were randomly split into five groups. The animals received ibotenic acid infusions into striatum
bilaterally. Locomotor activities of rats were assessed by open-field apparatus. Results. Our results showed that mild
forced treadmill exercise and GABA-B could significantly increase distance in open field and decrease anxietybehavior
in treadmill and drug groups than lesion group (P=0.008 and P=0.001 respectively). Conclusion. There is
no significant difference between treadmill and drug groups. So, mild forced treadmill exercise and baclofen could
improve motor dysfunction of lesion by ibotenic acid injection in striatum and anxiety-behavior.
Machine summary:
The Effects of Mild Forced Treadmill Exercise and GABA-B Agonist on Locomotor Activity and Anxiety-Behavior in Rats with Striatum Dysfunction 1Shaghayegh Modaberi, 1Mehdi Shabazi*, 2Nasser Naghdi, 1Abolfazl Bagherzadeh 1Department of Motor Learning, Faculty of Sport Sciences, University of Tehran, Tehran, Iran.
in this study, we examine the role of mild forced treadmill exercise and GABA-B agonist on locomotor activity and anxiety-behavior dysfunction of ibotenic acid injection in striatum.
Our results showed that mild forced treadmill exercise and GABA-B could significantly increase distance in open field and decrease anxiety- behavior in treadmill and drug groups than lesion group (P=0.
So, mild forced treadmill exercise and baclofen could improve motor dysfunction of lesion by ibotenic acid injection in striatum and anxiety-behavior .
Also, present research focuses on the role of mild forced treadmill exercise on locomotor activity and anxiety- related behaviors after stereotaxic rats were bilaterally injected ibotenic acid in striatum.
We evaluated the effects of Ibotenic acid-induced striatum lesion and baclofen injection in internal globus pallidus on locomotors activity and rearing (frequency with which the animal stood on hind legs in open- field) according to the animals’ performance in the open field (31).
Our results showed that ibotenic acid injection in striatum impaired locomotor activity and anxiety-behavior in the animal model.
Consistent with our findings, Pietrelli, Lopez- Costa, Goni, Brusco, Basso (2012) indicated that regular and chronic aerobic exercise has time and dose-dependent neuroprotective and restorative effects on physiological brain aging and reduces anxiety-related behaviors (47).
Mild forced treadmill exercise and GABA-B agonist improve motor dysfunction and reduce anxiety-behavior in animals with striatum damage by ibotenic acid injection.