Abstract:
Introduction: lL-17 and IL-18 are pro-inflammatory
cytokines. The aim of present study is to evaluate the effect
of endurance training on IL-17 and IL-18 in heart tissue of
rats which have been poisoned by cadmium.
Material & Methods: Twenty Wistar rats were randomly
divided into four groups: 1) control, 2) sham, 3) cadmium
and 4) high intensity interval training (HIIT training) with
cadmium. HIIT training was performed 8 weeks and 3 days a
week (80 to 110% of their VO2max). Cadmium groups received
2mg/kg cadmium intraperitoneally everyday. At the end of
protocol, the rats were sacrificed and their heart tissues were
prepared to measure gene expression of IL-17 and IL-18. The
data was analyzed by independent sample t-test and one-way
ANOVA (P≤ 0.05).
Results: The HIIT training led to significantly reducing IL-17
and IL-18 gene expression in heart issue of rats (P= 0.001).
Conclusion: The 8 weeks of HIIT training will improve the
levels of pro-inflammatory cytokines in rats which have been
poisoned by cadmium.
Machine summary:
Eight weeks of high intensity interval training improve the expression of interleukin-17 and interleukin-18 genes in the heart tissue of cadmium-poisoned rats Ahmad Ahmadloo1, Sirous Farsi2*, Mohammad Ali Azarbayjani3 Received: 9 September 2017/ Accepted: 18 December 2017 (1) Ph. D candidate in Exercise Physiology, Department of Physical Education, Larestan branch, Islamic Azad University, Larestan, Iran (2) Assistant Professor in Exercise Physiology, Department of Physical Education, Larestan branch, Islamic Azad University, Larestan, Iran (3) Professor in Exercise Physiology, Department of Physical Education, Central Tehran branch, Islamic Azad University, Tehran, Iran (*) Assistant Professor in Exercise Physiology E-mail: Sirous.
The aim of present study is to evaluate the effect of endurance training on IL-17 and IL-18 in heart tissue of rats which have been poisoned by cadmium.
Conclusion: The 8 weeks of HIIT training will improve the levels of pro-inflammatory cytokines in rats which have been poisoned by cadmium.
Numerous studies have confirmed the fact that severe interval exercises increase the levels of pre-inflammatory cytokines such as IL-6, IL-17 and IL-18 in athlete's body, and on the other hand, regular intensive endurance exercises with mean severity modifies these cytokines in various tissues, including the cardiovascular system (26-28).
So, the purpose of this study was to investigate the effect of HIIT exercises on the inflammation in the heart tissue of cadmium-poisoned rats.
5. Conclusion The results of this study showed that performing HIIT exercises significantly reduces the levels of IL-17 and IL-18 which can increase inflammation due to cadmium intake.