Abstract:
Objectives: The effect of metformin on weight changes and some metabolic parameters in
patients with schizophrenia and schizoaffective disorder was investigated in this study.
Methods: As a randomized double-blind controlled clinical trial, this study was performed from
2018 to 2019. A total of 66 obese patients (BMI≥27) with schizophrenia and schizoaffective
disorder, hospitalized in the departments of Razi Psychiatric Hospital, entered the study;
then, they were randomly divided into intervention and control groups after completing the
informed consent form. The patients received metformin or placebo for 12 weeks. The dose
of metformin was gradually increased and in case of a patient’s tolerance, was prescribed up
to 500 mg twice daily. During the study, all patients received their previous therapies. The
variables included BMI, weight, waist circumference, lipid profile, and fasting blood glucose,
which were studied at the beginning of the study and at weeks 4, 8, and, 12. The data were
analyzed, using a post hoc test by SPSS software.
Results: The results showed a significant decrease in weight (3.5 kg) and BMI (1.30) at the
end of the week 12, and there was a significant reduction in waist circumference (5.9 cm) at
the end of the week 8 compared to the placebo group (P<0.05). Moreover, metformin had no
significant effect on fasting blood glucose and lipid profile in comparison with the placebo
group.
Discussion: Based on the findings of this study, by reducing the weight, waist circumference,
and BMI, metformin can have a significant role in decreasing the complications of obesity
and metabolic disorders in patients with schizophrenia and schizoaffective disorder. Therefore,
given that the complications of metformin are low and transient, it can be recommended as a
safe and tolerable drug in obese patients with schizophrenia and schizoaffective disorder.