خلاصة:
Background. It seems that based on the independent effects of physical activity and flax oil on pain, it is possible
the interactions of these two effects reduces or mitigate the impact of pain or strengthen it. Objectives. This study
investigates the effect of high-intensity interval training (HIIT) and flaxseed oil supplementation on hippocampal
BDNF expression and pain feeling in male rats. Methods. Twenty adult Wistar rats were randomly divided into four
groups (five in each group) including control-saline (CS), training-saline (TS), control-flaxseed oil (CO), and
training-flaxseed oil (TO). The training groups were given HIIT program (10 weeks, five sessions in week) on a
rodent treadmill at 90–95% of VO2 max and supplement groups also received flaxseed oil (100 mg/kg per cage).
Pain threshold was assessed by the hot plate test at a temperature of 55 ± 0.5 °C five days after the last session
training. Then rats were sacrificed, their hippocamp tissue frizzed, and sent to laboratory to determine the BDNF
gene expression. Results. The results showed that training significantly induced higher hippocampal BDNF mRNA
expression (P=0.001) and lower pain threshold (P=0.02). Training-flaxseed oil combination group induced
significant increase in BDNF expression (P=0.04). There were no significant differences between the other groups.
Conclusion. The present study showed the useful role of flaxseed oil supplement and HIIT program in increasing an
important factor for Alzheimer's disease (BDNF gene). It also showed that, although HIIT may be accompanied with
reduced pain threshold and increased pain feeling, it has beneficial effects on memory enhancement gene (BDNF).
ملخص الجهاز:
The Effects of High-Intensity Interval Training with Supplementation of Flaxseed Oil on BDNF mRNA Expression and Pain Feeling in Male Rats 1Saleh Rahmati-Ahmadabad, 1Mohammad Ali Azarbayjani*, 2Mohammad Nasehi 1Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
This study investigates the effect of high-intensity interval training (HIIT) and flaxseed oil supplementation on hippocampal BDNF expression and pain feeling in male rats.
The present study showed the useful role of flaxseed oil supplement and HIIT program in increasing an important factor for Alzheimer's disease (BDNF gene).
Animal studies have shown that daily physical activities cause the release of different neurotransmitters in the brain such as dopamine, norepinephrine, and especially the release of BDNF, which is why the release of neurotripin is related to an increase in learning speed and protects it better after a week (11).
With respect to BDNF, regardless of numerous reports about the positive impact of physical activity on BDNF, to date no study has investigated the effect of interactive HIIT and use of flax oil on the gene expression of hippocampus BDNF in rats.
Thus, the present research will examine the effects of HIIT program and flaxseed oil supplement on the hippocampus BDNF gene expression and pain induced in male rats.
Data results in interactive group showed significant increase in hippocampus BDNF gene expression in rats (F =4.
CONCLUSION Overall, the present study showed that periodic intense exercise, despite reducing the pain threshold, can increase BDNF expression as one of the factors facilitating the improvement of Alzheimer’s disease.