خلاصة:
Background. Cardiac rehabilitation program is aimed at reducing secondary risk factors and improving function in
patients undergoing coronary artery bypass grafting run which ultimately may delay or reduce mortality in patients.
A major component of cardiac rehabilitation program is exercise. Objective(s). This study is aimed at evaluating the
effect of aquatic and dryland training on Peroxisome Proliferator Activated Receptor-ɑ (PPAR-α) gene expression in
middle-aged women’s peripheral blood mononuclear cells (PBMNCs) after coronary artery bypass
grafting. Methods. Thirty middle-aged women with cardiovascular disease were categorized into three groups
comprising control (CON), aquatic resistance training (ART) and dryland resistance training (DRT). The dryland
training program lasted for eight weeks of resistance training (3 sessions per week/ 60 minutes per session) and
included two to three sets of 12-15 repetitions with 60% of 1RM. The aquatic resistance training lasted for eight
weeks (3 sessions per week/ 60 minutes per session), with 60 to 80% of 1RM for each exercise primarily. Fasting
blood samples were taken from all participants 48 hours both before the beginning of the training program and after
the last training session. PPARα relative gene expression was identified by Real-Time PCR method. Results. It
is showed a significant increase in the relative PPARɑ gene expression in both aquatic and dryland resistance
training groups (F= 15.573, P= 0.001). It is found a significant difference in aquatic and dryland resistance training
groups as regards PPARɑ gene expression (P= 0.001, t= -6.954; P= 0.001, t= -5.871; respectively). Conclusion. The
results revealed that both of them on land and water training, increase PPARɑ gene expression in middle-aged
women after coronary artery bypass and a possible reverse cholesterol transport process can be improved, so it is
recommended that this type of training program, cardiac rehabilitation should be employed.
ملخص الجهاز:
The Effect of Aquatic and Dryland Resistance Training on Peroxisome Proliferator Activated Receptor-ɑ Gene Expression in Middle-aged Women’s Peripheral Blood Mononuclear Cell after Coronary Artery Bypass Grafting 1Leili Zeiaadini Dashtkhaki, 2Amir Rashid Lamir*, 3Saeed Naghibi 1Department of Sport Science, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran.
This study is aimed at evaluating the effect of aquatic and dryland training on Peroxisome Proliferator Activated Receptor-ɑ (PPAR-α) gene expression in middle-aged women’s peripheral blood mononuclear cells (PBMNCs) after coronary artery bypass grafting.
The results revealed that both of them on land and water training, increase PPARɑ gene expression in middle-aged women after coronary artery bypass and a possible reverse cholesterol transport process can be improved, so it is recommended that this type of training program, cardiac rehabilitation should be employed.
As a pioneering research in the field of cardiac rehabilitation, the current study is aimed at examining PPAR α gene expression in peripheral blood mononuclear cells (PBMNCs) in middle-aged women having had CABG, after 8 weeks of aquatic and dryland resistance training programs.
RESULTS The results revealed a significant increase in PPAR ɑ relative gene expression in PBMN cells in the aquatic and dryland resistance training groups compared to the control group (F=15.
As a pioneering research in the field of cardiac rehabilitation, the present study is aimed at investigating PPAR α gene expression in PBMN cells in middle-aged women having had CABG, after 8 weeks of aquatic and dryland resistance training programs.