Abstract:
Actins are small globular filaments functioning in cell processes like muscle contraction, and stabilized to the
sarcomeric Z- discs by actin binding proteins (actinins). One of the important gene coding for actin binding proteins
in fast twitch fibers is alpha- actinin- 3 (ACTN3). In this research, we have conducted a gene profile study
investigating the genotype and allele distributions of ACTN3 R577X polymorphism in Turkish professional hip- hop
and latin dancers and compared them to non-dancers as a control group. 30 professional dancers and non-dancers
were recruited for the study. A genotyping procedure was carried out by a newly introduced four-primer PCR
methodology. For statistical analysis, the Chi-square test was used to compare data between the groups (p<0,05
evaluated as significant). Numbers and the percentages of dancers were 2 (7%), 21 (70%) and 7(23%) for RR, RX
and XX genotypes, respectively. The same numbers and the percentages were 15 (50%), 8 (15%) and 7 (23%) for
RR, RX and XX genotypes, respectively, for the controls. Allele numbers and percentages of the R allele were 38
(63%) and 25 (42%) for the control and dancers, respectively. For X allele, the respective number for control and
dancers were 22 (37%) and 35 (58%). No significant difference was detected between the groups in the terms of
genotypes and alleles. Only RX genotype was significantly different between dancers and non-dancers (p<0,05). The
results of the present and the first study, associating professional dancers and ACTN3 R577X polymorphism, is
suggesting that RX genotype may have an genetic advantage for the physical predisposition for dancing, at least in
the terms of ACTN3 R577X polymorphism. Prospective studies with extended numbers of dancers focusing on the
influence of ACTN3 R577X polymorphism are required for confirmation of these findings.
Machine summary:
"com Received: 20/03/2016 Accepted: 10/06/2016 Alpha-actinin-3 R577X Polymorphism Profile of Turkish Professional Hip-Hop and Latin Dancers 1,2Korkut Ulucan*, 1Betul Biyik, 1Sezgin Kapici, 2Canan Sercan, 1Oznur Yilmaz, 1Tunc Catal 1Üsküdar Univerity, Haluk Turksoy Sok. No:14, Altunizade, Üsküdar, İstanbul, Turkey.
In this research, we have conducted a gene profile study investigating the genotype and allele distributions of ACTN3 R577X polymorphism in Turkish professional hip- hop and latin dancers and compared them to non-dancers as a control group.
The results of the present and the first study, associating professional dancers and ACTN3 R577X polymorphism, is suggesting that RX genotype may have an genetic advantage for the physical predisposition for dancing, at least in the terms of ACTN3 R577X polymorphism.
The aim of this study was to determine the genotype and allele distribution of ACTN3 R577X polymorphism in Turkish professional dancers and assess the impact of this polymorphism on dancing activity.
Dancing activity is considered to have an aerobic performance, extending from minutes to hours, making high-intensity movement such as quick moving, jump, rotation and leap; our findings gave us some evidence about the genetic structure of dancers, at least in the terms of ACTN3 R577X polymorphism.
(2014) examined the association of body composition, flexibility, and injury risk to genetic polymorphisms including ACE ID, ACTN3 RX, and COL5A1 polymorphisms in Korean ballet dancers and reported that ACE ID and ACTN3 RX polymorphisms were related with ballerinas’ physical performance."